CuidArte, Enferm; 16 (2), 2022
Publication year: 2022
Introdução:
O câncer de mama compreende a principal neoplasia maligna que acomete as mulheres brasileiras, com
destaque nos índices de mortalidade. O diagnóstico precoce é preconizado através da mamografia, a qual, quando
alterada, sugere realizar biópsia para estudo histopatológico e, caso confirmado um carcinoma mamário, acrescenta-se
o estudo imuno-histoquímico para determinação de fatores prognósticos e preditivos para o tumor. Objetivos:
Levantar
os resultados de análise imuno-histoquímica dos carcinomas mamários diagnosticados pelo Serviço de Patologia do
Hospital Emílio Carlos (Catanduva-SP) e estabelecer os principais subtipos moleculares do câncer de mama encontrados
nessa população. Material e Método:
O estudo foi transversal e retrospectivo, a partir dos relatórios de imunohistoquímica dos carcinomas. Foram relatados idade, sexo, subtipo histológico do tumor e positividade imunohistoquímica para receptor de estrogênio, receptor de progesterona, fator de crescimento epidérmico humano 2, índice
de proliferação celular e E-caderina. Os casos foram classificados conforme os critérios estabelecidos pelo Consenso de
St. Gallen e os dados apresentados por meio de gráficos e tabelas. Resultados:
A amostra foi constituída por n=210
casos de carcinomas mamários, com idade média de 58 anos e predominantemente do sexo feminino. O tipo histológico
predominante foi o carcinoma mamário invasivo do tipo não especial. A expressão de receptor de estrogênio ocorreu em
92,86%, progesterona 80,48%, HER2 32,38% e Ki67 alto em 70%. O principal subtipo molecular foi o luminal B.
Conclusão:
Os casos de carcinomas mamários da microrregião de Catanduva apresentam diferenças quando comparados
com estudos nacionais, porém similares a outros de caráter regional
Introduction:
Breast cancer is the main malignant neoplasm that affects Brazilian women, especially in mortality rates.
Early diagnosis is recommended through mammography, which, when altered, suggests biopsy for histopathological
study and, if a breast carcinoma is confirmed, the immunohistochemical study is added for determination of prognostic
and predictive factors for the tumor. Objectives:
To survey the results of immunohistochemical analysis of breast
carcinomas diagnosed by the Pathology Service of Hospital Emílio Carlos (Catanduva-SP) and to establish the main
molecular subtypes of breast cancer found in this population. Material and Method:
The study was cross-sectional and
retrospective, from the reports of immunohistochemistry of carcinomas (CEP/UNIFIPA number 4737142). Age, sex,
histological subtype of the tumor and immunohistochemical positivity for estrogen receptor, progesterone receptor,
human epidermal growth factor 2, cell proliferation index and E-cadherin were reported. The cases were classified
according to the criteria established by the St. Gallen Consensus and the data presented by means of graphs and tables.
Results:
The sample consisted of n=210 cases of breast carcinomas, with a mean age of 58 years and predominantly
female. The predominant histological type was invasive breast carcinoma of the non-special type. Estrogen receptor
expression occurred in 92.86%, progesterone 80.48%, HER2 32.38% and high Ki67 in 70%. The main molecular subtype
was luminal B. Conclusion:
The cases of breast carcinomas in the microregion of Catanduva present differences when
compared to national studies, but similar to other regional studies
Introduction:
Breast cancer comprises the main malignant neoplasm that affects Brazilian women, especially in mortality
rates. Early diagnosis is recommended through mammography, which, when altered, suggests biopsy for
histopathological study and, if confirmed a breast carcinoma, the immuno-study is addedto determine prognostic and
predictive factors for the tumor. Objectives:
To collect the results of immunohistochemical analysis of breast carcinomas diagnosed by the Pathology Service of the Emílio Carlos Hospital (Catanduva-SP) and to establish the main molecular
subtypes of breast cancer found in this population. Methods:
The study was cross-sectional and retrospective, from the
reports of immunohistochemistry of carcinomas. Age, sex, tumor histological subtype and immunohistochemical positivity
for estrogen receptor, progesterone receptor, human epidermal growth factor 2, cell proliferation index and E-cadherin
were reported. The cases were classified according to the criteria established by the St. Gallen Consensus and the data
presented through graphs and tables. Results:
The sample consisted of n = 210 cases of breast carcinomas, with a mean
age of 58 years and predominantly female. The predominant histological type was nonspecial invasive breast carcinoma.
The expression of estrogen receptor occurred in 92.86%, progesterone 80.48%, HER2 32.38% and Ki67 high in 70%.
The main molecular subtype was luminal B. Conclusion:
The cases of breast carcinomas in the Catanduva microregion
show differences when compared to national studies, but similar to others of regional character
